Akuamma, known botanically as picralima nitida, is a large brown medicinal seed that comes in the grapefruit-sized fruit of an African shrub. We offer dried African-grown seed. Akuamma has been compared to kratom. Unlike kratom, there are not different strains of akuamma, and akuamma is available for sale worldwide.
Akuamma contains a number of interesting alkaloids, including akuammine, dihydoakuammine, akuammidine, akuammicine, akuammigine and pseudoakuammigin and perecine. This hefty list of compounds contains both opioid agonists and antagonists. Akuammine, also known as vincamajordine, is an indole alkaloid, which is structurally related to mitragynine and yohimbine (found in yohimbe). Vincamajordine gets its name from another plant,that contains the same compound, vinca minor, or commonly known as periwinkle. Akuamma seeds contain about .56% akuammine by dry weight, making it the most abundant compound, and therefore it is the compound that gets the most attention.
Akuammine is a weak mu opioid receptor antagonist, meaning it can essentially plug into the receptor and block other compounds that would normally bind to the same receptor. Naxalone, sold under the brand name Narcan, which is used to reverse opioid overdoses, is an aggressive example of this type of receptor agonist. Although most often used to help withdraw from opiates, many of these types of antagonists still produce analgesia. It appears that this may be the case with akuammine because the seeds have traditionally been used for analgesia in African medicine. More research into the combined effect of the many other compounds found in the seed could help unlock some of the mystery of the exact roles each of these play. But it does seem akuammicine is a partial kappa receptor agonist while akuammidine was some binding activity for both receptors. We can supply these to everywhere in the U.S. We offer akuamma in powdered, whole seed and extract form.
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